For a given measurement, how would you treat the smallest number of significant figures in calculations?

The correct choice emphasizes that the smallest number of significant figures in any calculation dictates the number of significant figures in the final answer. This principle is a fundamental rule in the treatment of significant figures during mathematical operations.

When performing calculations, each number contributes to the precision of the result based on its significant figures. If one of the numbers in the calculation has fewer significant figures, it effectively limits the precision of the final result. For instance, if you were adding or multiplying numbers with different significant figures, the result cannot be more precise than the least precise measurement.

For example, if you were calculating the sum of 12.11 (which has 4 significant figures) and 0.3 (which has 1 significant figure), the result should be reported to just 1 significant figure, which reflects the limitation imposed by the least precise measurement. This ensures that the reported results accurately represent the uncertainty inherent in the measurements involved. The other options do not align with this significant figure rule.